The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …

The question of what and how to measure ecological resilience has been troubling
ecologists since Holling 1973s seminal paper in which he defined resilience as the ability of …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

Therapy resistance and tumour relapse after drug therapy are commonly explained by
Darwinian selection of pre-existing drug-resistant, often stem-like cancer cells resulting from …

The development of drug resistance, the prime cause of failure in cancer therapy, is
commonly explained by the selection of resistant mutant cancer cells. However, dynamic …

We present a review of the recently developed landscape and flux theory for non-equilibrium
dynamical systems. We point out that the global natures of the associated dynamics for non …

The generation of cellular diversity during development involves differentiating cells
transitioning between discrete cell states. In the 1940s, the developmental biologist Conrad …