The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
E Karran, B De Strooper - Nature Reviews Drug Discovery, 2022 - nature.com
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate
clinical efficacy. However, four anti-Aβ antibodies have been shown to mediate the removal …
clinical efficacy. However, four anti-Aβ antibodies have been shown to mediate the removal …
[HTML][HTML] Mouse models of Alzheimer's disease
M Yokoyama, H Kobayashi, L Tatsumi… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …
[HTML][HTML] The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
APP mouse models for Alzheimer's disease preclinical studies
H Sasaguri, P Nilsson, S Hashimoto, K Nagata… - The EMBO …, 2017 - embopress.org
Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …
indispensable for understanding molecular mechanisms and advancing preclinical studies …
[HTML][HTML] The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome
Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …
examining plaque-associated proteins have shown these additional proteins are important; …
Single App knock-in mouse models of Alzheimer's disease
T Saito, Y Matsuba, N Mihira, J Takano, P Nilsson… - Nature …, 2014 - nature.com
Experimental studies of Alzheimer's disease have largely depended on transgenic mice
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
Prions, prionoids and protein misfolding disorders
C Scheckel, A Aguzzi - Nature Reviews Genetics, 2018 - nature.com
Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …
'prion'was first nominated to express the revolutionary concept that a protein could be …
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
E Karran, M Mercken, BD Strooper - Nature reviews Drug discovery, 2011 - nature.com
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …
[HTML][HTML] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
M Maruyama, H Shimada, T Suhara, H Shinotoh, B Ji… - Neuron, 2013 - cell.com
Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of
neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …
neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …