Genomic instability is widespread during early embryo development. Aneuploidy,
mosaicism, and copy number variants (CNVs) commonly appear in human preimplantation …

Implantation rate decreases and miscarriage rate increases with advancing maternal age.
The oocyte must be the locus of reproductive aging because donation of oocytes from …

Telomerase and telomeres are important for indefinite replication of stem cells. Recently,
telomeres of somatic cells were found to be reprogrammed to elongate in induced …

Embryonic stem cells (ESCs) provide a valuable in vitro model for testing toxicity of
chemicals and environmental contaminants including cigarette smoke. Mouse ESCs were …

Cigarette smoke is associated with high risk of lung, cardiovascular, and degenerative
diseases, reduced fertility, and possibly the health of newborns. Cigarette smoke contains …

Maternal aging has been reported to reduce oocyte quality and, in turn, lower the
developmental potential of the resulting embryos. Here, we show that maternally aged …

Kaempferol (KAE) is a natural flavonoid present in different plant species and exhibits anti‐
inflammatory, antioxidant, and anticancer therapeutic properties. In the present study, we …

Advanced maternal age (AMA) is known to reduce fertility, increases aneuploidy in oocytes
and early embryos and leads to adverse developmental consequences which may …

The mammalian oocyte has the unique feature of supporting fertilization and normal
development, while capable of reprogramming nuclei of somatic cells toward pluripotency …

Mouse embryonic stem cells (mESCs) have the capability to undergo unlimited cell division
and differentiate into derivatives of all three embryonic germ layers. These fundamental …