In this article, we analyze the performance of a cooperative spatial multiplexing scheme
using amplify and forward relays over Rayleigh fading channels. We propose a simple user …

Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

There is a need for methodological scrutiny in the economic assessment of personalized
medicine. In this article, we present a list of 10 specific issues that we argue pose specific …

Given the rapid development of genetic tests, an assessment of their benefits, risks, and
limitations is crucial for public health practice. We performed a systematic review aimed at …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting
treatment to a prespecified patient population, has always been a long-time goal within …

References 1. regan mm, Leyland-Jones B, Bouzyk m, et al. CyP2D6 genotype and
tamoxifen response in postmenopausal women with endocrine-responsive breast cancer …

Clinical and histopathologic characteristics of breast cancer have long played an important
role in treatment decision-making. Well-recognized prognostic factors include tumor size …

Tamoxifen is a pro-drug widely used in breast cancer patients to prevent tumor recurrence.
Prior work has revealed a role of cytochrome and sulfotransferase enzymes in tamoxifen …

Background CYP2D6 is a key enzyme in tamoxifen metabolism, transforming it into its main
active metabolite, endoxifen. Poor CYP2D6 metabolizers (PM) have lower endoxifen plasma …