Male infertility is a heterogeneous condition of largely unknown etiology that affects at least
7% of men worldwide. Classical genetic approaches and emerging next-generation …

First reported in the 1800s, germ cell granules are small nonmembrane bound RNA‐rich
regions of the cytoplasm. These sites of critical RNA processing and storage in the male …

Katanin microtubule-severing enzymes are crucial executers of microtubule regulation.
Here, we have created an allelic loss-of-function series of the katanin regulatory B-subunit …

Male germ cells establish a unique heterochromatin domain, the XY-body, early in meiosis.
How this domain is maintained through the end of meiosis and into post-meiotic germ cell …

Spermatogenesis is a delicate and complex biological process in which spermatogonial
stem cells continue to proliferate and differentiate into mature spermatozoa, maintaining …

Alpha, beta, and gamma tubulins are essential building blocks for all eukaryotic cells. The
functions of the non-canonical tubulins, delta, epsilon, and zeta, however, remain poorly …

The development and function of male gametes is dependent on a dynamic microtubule
network, yet how this is regulated remains poorly understood. We have recently shown that …

The transition zone is a specialised gate at the base of cilia/flagella, which separates the
ciliary compartment from the cytoplasm and strictly regulates protein entry. We identified a …

Katanin microtubule severing enzymes are potent M-phase regulators in oocytes and
somatic cells. How the complex, and evolutionarily critical, male mammalian meiotic spindle …

Transcriptomic analyses of germ cells at different stages of differentiation have shed light on
the transcriptional and post-transcriptional mechanisms regulating gene expression that …