Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

Summary Background Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global
threat, but the distribution and clinical significance of carbapenemases are unclear. The aim …

We describe the global molecular epidemiology of 229 carbapenemase-producing
Escherichia coli in 36 countries during 2015–2017. Common carbapenemases were …

Adaptation to selective pressures is crucial for clinically important pathogens to establish
epidemics, but the underlying evolutionary drivers remain poorly understood. The current …

Background Data on risk factors for carbapenem-resistant Enterobacterales (CRE) with
wider applicability are needed to inform preventive measures and efficient design of …

Carbapenem-resistant Enterobacterales (CRE) remain a significant public health threat,
and, despite recent approvals, new antibiotics are needed. Severe infections caused by …

Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the
most problematic antimicrobial-resistant bacteria. We sought to elucidate the international …

The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …