Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …

Hybridization and polyploidy are pervasive evolutionary features of flowering plants and
frequent among some animal groups, such as fish. These processes always lead to novel …

Breast cancer is a widely studied genetic disease that has a clear division between an initial
stage, starting with the atypical ductal hyperplasia progressing to ductal carcinoma in situ …

Clostridium perfringens phospholipase C (CpPLC) plays a key role in the pathogenesis of
gas gangrene, an acute and life-threatening infection in humans. CpPLC leads to the …

In a previous effort, we developed a model to study the hypothesis of gene dosage
compensation in the limited data set of NCI60 cancer cell lines. Currently, we have …

In a previous work we developed a biocomputational platform to automatically construct
mathematical models of microRNA-transcription factor (TF) regulatory network to study gene …

Chemotherapeutic drugs have been used as important strategies in cancer treatment.
However, chemotherapy-resistant tumors arise especially in relapsing and progressive …

Epithelial Mesenchymal Transition (EMT) is a common process in many cases of cancer that
leads to metastasis. Current understanding of this process has determined that the capability …

The genetic instability caused by the disruption of the mechanism of the DNA-damage
response (DDR) has been linked to cancer development. One of the most important and …

The control of angiogenesis in cancer has been recognized as a promising therapeutic
target for many diseases like cancer. Specifically, the Angiopoietin-2-Vascular Endothelial …