Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior

MJ Dolleman-van der Weel, AL Griffin, HT Ito… - Learning & …, 2019 - learnmem.cshlp.org
The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of
hippocampal and cortical structures and is a fundamental substrate for cognition. A common …

Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

CB Klune, B Jin, LA DeNardo - Elife, 2021 - elifesciences.org
The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

How development sculpts hippocampal circuits and function

R Cossart, R Khazipov - Physiological Reviews, 2022 - journals.physiology.org
In mammals, the selective transformation of transient experience into stored memory occurs
in the hippocampus, which develops representations of specific events in the context in …

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

M Richter, N Murtaza, R Scharrenberg, SH White… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …

Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors

T Korotkova, A Ponomarenko, CK Monaghan… - Neuroscience & …, 2018 - Elsevier
Abstract The theta oscillation (5–10 Hz) is a prominent behavior-specific brain rhythm. This
review summarizes studies showing the multifaceted role of theta rhythm in cognitive …

Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

O Blanquie, JW Yang, W Kilb, S Sharopov, A Sinning… - Elife, 2017 - elifesciences.org
Programmed cell death widely but heterogeneously affects the developing brain, causing
the loss of up to 50% of neurons in rodents. However, whether this heterogeneity originates …

[HTML][HTML] A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

SH Bitzenhofer, JA Pöpplau, M Chini, A Marquardt… - Neuron, 2021 - cell.com
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development
and might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic …

Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task

JF Morici, NV Weisstaub… - Proceedings of the …, 2022 - National Acad Sciences
Remembering life episodes is a complex process that requires interaction among multiple
brain areas. It is thought that contextual information provided by the hippocampus (HPC) can …

Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks

SH Bitzenhofer, J Ahlbeck, A Wolff, JS Wiegert… - Nature …, 2017 - nature.com
Coordinated activity patterns in the developing brain may contribute to the wiring of neuronal
circuits underlying future behavioural requirements. However, causal evidence for this …