Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

In rat models of drug relapse and craving, cue-induced cocaine seeking progressively
increases after withdrawal from the drug. This' incubation of cocaine craving'is partially …

High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …

AMPA receptors are tetrameric glutamate‐gated ion channels that mediate a majority of fast
excitatory neurotransmission in the brain. They exist as calcium‐impermeable (CI‐) and …

In animal models of drug addiction, cocaine exposure has been shown to increase levels of
calcium-permeable AMPA receptors (CP-AMPARs) in two brain regions that are critical for …

Drug craving and relapse to drug use during abstinence are defining features of addiction.
Evidence indicates that drug craving and relapse in humans are often provoked by acute …

Urges to eat are influenced by stimuli in the environment that are associated with food (food
cues). Obese people are more sensitive to food cues, reporting stronger craving and …