Dysfunction of p53 is observed in the many malignant tumors. In cervical cancer, p53 is
inactivated by degradation through the complex with human papilloma virus (HPV) …

This study evaluated the immunohistochemical (IHC) expression of p16, p53 and Ki-67 in
precancerous lesions and in cervical cancer (CC). Identification and review of publications …

Abstract microRNAs (miRNAs) are small non-coding RNA molecules of 21-24 nt that
regulate the expression of other genes by transcriptional inhibition or translational …

Purpose: The purpose of this research was to evaluate the clinical significance of p16INK4A,
p14ARF, p53, and proliferating cell nuclear antigen (PCNA) expression in tumor progression …

The World Health Organization (WHO) classification for tumors of the cervix has been
revised recently in collaboration with the International Society of GynecolOgical …

The dominant paradigm in cancer treatment is that cancer cells die from the common
pathway of apoptosis subsequent to DNA damage by anticancer agents and that cells …

Background Recent evidence indicated that the aberrant expression of microRNA plays a
crucial role in the development of cervical cancer. The overall shorter survival was strongly …

Objective: The present study was designed to analyse the relationship between apoptosis
related proteins (bcl-2 and bax), tumour suppressor protein p53, proliferation markers …

Aberrant miRNA expression is well recognized as an important step in the development of
cancer. Close to 70 microRNAs (miRNAs) have been implicated in cervical cancer up to …

Background Cisplatin is the main chemotherapeutic drug for the treatment of cervical
cancers, however resistance to cisplatin is increasingly common and therefore has limited …