Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Aminoglycosides are a class of antibiotics that bind to ribosomal RNA and exert pleiotropic
effects on ribosome function. Amikacin, the semisynthetic derivative of kanamycin, is …
effects on ribosome function. Amikacin, the semisynthetic derivative of kanamycin, is …
Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin
NP Parajuli, CS Mandava, MY Pavlov… - Nucleic Acids …, 2021 - academic.oup.com
How aminoglycoside antibiotics limit bacterial growth and viability is not clearly understood.
Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically …
Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically …
Adaptive Evolution of the Bacterial Translation Machinery
A De Tarafder - 2024 - diva-portal.org
The process of protein synthesis via translation is of paramount importance for the existence
of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion …
of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion …
Investigating the Molecular Mechanism of Ribosome Recycling
SM Seely - 2024 - utmb-ir.tdl.org
In all living cells, the ribosome translates the genetic information carried by messenger
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …
Molecular Interplay of Antibiotics on the Bacterial Ribosome
NP Parajuli - 2022 - diva-portal.org
Inhibition of protein synthesis is one of the most common modes of action for medically
useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct …
useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct …