Psychosocial stress is an important precursor of disease and reduced quality of life in
humans. The biological pathways between stress exposure and pathophysiological …

The endothelium forms a vast network that dynamically regulates vascular barrier function,
coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely …

Abstract Cancer-Associated Fibroblasts (CAFs) were shown to orchestrate tumour-
promoting inflammation in multiple malignancies, including breast cancer. However, the …

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2)
inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular …

Corneal alkali burn (AB) injury is the most common sight-threatening injury that is highly
associated with oxidative stress, inflammation, apoptosis, angiogenesis, and cell deficiency …

Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory
cells and soluble mediators play critical roles throughout arterial plaque development and …

Extracellular vesicles (EVs) are important elements of intercellular communication. A
plethora of different, occasionally even opposite, physiologic and pathologic effects have …

The complement system represents an evolutionary old and critical component of innate
immunity where it forms the first line of defense against invading pathogens. Originally …

Oxidized low-density lipoprotein (OxLDL) is a risk factor for atherosclerosis, due to its role in
endothelial dysfunction and foam cell formation. Tissue-resident cells such as macrophages …

The aim of the present study was to investigate the potential role of regulated in
development and DNA damage response 1 (REDD1) in LPS-induced vascular endothelial …