Abstract Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that
prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL …

Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation,
differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase …

Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …

Fibroblast growth factor receptor (FGFR) dysregulation is involved in a variety of
tumorigenesis and development. Cholangiocarcinoma is closely related with FGFR …

Recently, FGFR4 has become a hot target for the treatment of cancer owing to its important
role in cellular physiological processes. FGFR4 has been validated to be closely related to …

Aberrant FGF19/FGFR4 signaling has been shown to be an oncogenic driver of growth and
survival in human hepatocellular carcinoma (HCC) with several pan-FGFR inhibitors and …

Fibroblast growth factor receptor 4 (FGFR4) has been identified as a potential target for the
treatment of hepatocellular carcinoma (HCC) with aberrant FGFR4 signaling because of its …

Background: Metastasis accounts for the high lethality of colorectal cancer (CRC) patients.
Unfortunately, the molecular mechanism manipulating metastasis in CRC is still elusive …

Metastasis accounts for more than 90% of cancer related mortality, thus the most pressing
need in the field of oncology today is the ability to accurately predict future onset of …

The pyrimidine scaffold represents one of the privileged structures in chemistry, and there
has been an increase in number of studies utilizing this scaffold and its derivatives. The …