HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate
the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization …

Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …

Abstract Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1)
gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are …

The structure determination of protein− protein complexes is a rather tedious and lengthy
process, by both NMR and X-ray crystallography. Several methods based on docking to …

Neutralizing antibodies (Nab) are a principal component of an effective human immune
response to many pathogens, yet their role in HIV-1 infection is unclear,,,,,. To gain a better …

We present the crystal structure at 2.7 angstrom resolution of the human antibody IgG1 b12.
Antibody b12 recognizes the CD4-binding site of human immunodeficiency virus–1 (HIV-1) …

The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent
on its avoidance of antibody-mediated neutralization. The virus elicits abundant, envelope …

More people were killed by smallpox during the twentieth century--over 300 million--than by
all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 …

Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1
(HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the …