Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

[HTML][HTML] Nanotechnology: a promising approach for delivery of neuroprotective drugs

S Naqvi, A Panghal, SJS Flora - Frontiers in Neuroscience, 2020 - frontiersin.org
Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …

[HTML][HTML] Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

B Oller-Salvia, M Sánchez-Navarro, E Giralt… - Chemical Society …, 2016 - pubs.rsc.org
Brain delivery is one of the major challenges in drug development because of the high
number of patients suffering from neural diseases and the low efficiency of the treatments …

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

X Zhou, QR Smith, X Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

[HTML][HTML] Nanogels as novel drug nanocarriers for CNS drug delivery

V Manimaran, RP Nivetha, T Tamilanban… - Frontiers in Molecular …, 2023 - frontiersin.org
Nanogels are highly recognized as adaptable drug delivery systems that significantly
contribute to improving various therapies and diagnostic examinations for different human …

Recent expansions of novel strategies towards the drug targeting into the brain

A Alexander, M Agrawal, A Uddin… - International journal …, 2019 - Taylor & Francis
The treatment of central nervous system (CNS) disorders always remains a challenge for the
researchers. The presence of various physiological barriers, primarily the blood–brain …

[HTML][HTML] Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke

S Parvez, M Kaushik, M Ali, MM Alam, J Ali… - Theranostics, 2022 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is one of the leading causes of death and disability resulting in
inevitable burden globally. Ischemic injury initiates cascade of pathological events …

Carbon nanostructures: The drug and the delivery system for brain disorders

TK Henna, VR Raphey, R Sankar, VKA Shirin… - International Journal of …, 2020 - Elsevier
Neurodegenerative disorders and brain tumors are major pathological conditions affecting
the brain. The delivery of therapeutic agents into the brain is not as easy as to other organs …