[HTML][HTML] SOD1, more than just an antioxidant
ECA Eleutherio, RSS Magalhães… - Archives of Biochemistry …, 2021 - Elsevier
During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …
concentration, they may cause cell damage. To combat this threat, the cell employs the …
Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases
JL Carey, L Guo - Frontiers in molecular biosciences, 2022 - frontiersin.org
Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …
membraneless organelles with essential cellular function. However, aberrant phase …
[HTML][HTML] Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer
J Chen, Y Wu, X Luo, D Jin, W Zhou, Z Ju, D Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Tumor metastasis of colorectal cancer (CRC) is the main cause of death in
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular
condensates, cellular compartments that concentrate macromolecules without surrounding …
condensates, cellular compartments that concentrate macromolecules without surrounding …
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
C Lagier-Tourenne, M Polymenidou… - Human molecular …, 2010 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
[HTML][HTML] RNA dysregulation in amyotrophic lateral sclerosis
Z Butti, SA Patten - Frontiers in genetics, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …
and is characterized by the degeneration of upper and lower motor neurons. It has become …
The role of FUS gene variants in neurodegenerative diseases
H Deng, K Gao, J Jankovic - Nature Reviews Neurology, 2014 - nature.com
The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …
progressive loss of specific groups of neurons. These diseases affect different populations …
The solution structure of FUS bound to RNA reveals a bipartite mode of RNA recognition with both sequence and shape specificity
FE Loughlin, PJ Lukavsky, T Kazeeva, S Reber… - Molecular cell, 2019 - cell.com
Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
The neurogenetics of alternative splicing
CK Vuong, DL Black, S Zheng - Nature Reviews Neuroscience, 2016 - nature.com
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …
Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis
The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …
structural information capable of both propagation and inducing severe neuropathology has …