Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

For many years, psychiatrists have tried to understand factors involved in response to
medications or psychotherapies, in order to personalize their treatment choices. There is …

Background Antidepressant treatment efficacy is low, but might be improved by matching
patients to interventions. At present, clinicians have no empirically validated mechanisms to …

In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …

Transcranial direct current stimulation (tDCS) is a promising method for altering the function
of neural systems, cognition, and behavior. Evidence is emerging that it can also influence …

The serotonin hypothesis of depression has played an important role in the history of
psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of …

This narrative review discusses how peripheral and central inflammation processes affect
brain function and structure in depression, and reports on recent peripheral inflammatory …

Highlights•The combination of data-driven machine learning and theory-driven
computational models holds great promise for psychiatry.•Machine-learning analyses of …

Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural
mechanisms for all psychiatric disorders remain unclear. A large body of research obtained …