Metabolism and role of glutamate in mammalian brain
M Erecińska, IA Silver - Progress in neurobiology, 1990 - Elsevier
Glutamic acid is an amino acid with multiple biological roles. In the animal world, it links the
metabolism of carbon and nitrogen and, depending on the need, serves either as a source …
metabolism of carbon and nitrogen and, depending on the need, serves either as a source …
Regulation of γ‐aminobutyric acid synthesis in the brain
DL Martin, K Rimvall - Journal of neurochemistry, 1993 - Wiley Online Library
γ‐Aminobutyric acid (GABA) is synthesized in brain in at least two compartments, commonly
called the transmitter and metabolic compartments, and because reglatory processes must …
called the transmitter and metabolic compartments, and because reglatory processes must …
Two genes encode distinct glutamate decarboxylases
MG Erlander, NJK Tillakaratne, S Feldblum, N Patel… - Neuron, 1991 - cell.com
Summary y-Aminobutyric acid (CABA) is the most widely distributed known inhibitory
neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in …
neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in …
Two forms of the γ‐aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions
DL Kaufman, CR Houser, AJ Tobin - Journal of neurochemistry, 1991 - Wiley Online Library
Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a
major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms …
major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms …
L‐DOPA‐induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin‐and glutamic acid decarboxylase mRNA
MA Cenci, CS Lee, A Björklund - European Journal of …, 1998 - Wiley Online Library
Rats sustaining unilateral near‐complete 6‐hydroxydopamine lesions of the mesostriatal
dopamine pathway received daily injections of 3, 4 dihydroxyphenyl‐l‐alanine (L‐DOPA, 8 …
dopamine pathway received daily injections of 3, 4 dihydroxyphenyl‐l‐alanine (L‐DOPA, 8 …
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.
DF Bu, MG Erlander, BC Hitz… - Proceedings of the …, 1992 - National Acad Sciences
We report the isolation and sequencing of cDNAs encoding two human glutamate
decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC 4.1. 1.15), GAD65 and GAD67 …
decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC 4.1. 1.15), GAD65 and GAD67 …
The structural and functional heterogeneity of glutamic acid decarboxylase: a review
MG Erlander, AJ Tobin - Neurochemical research, 1991 - Springer
Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid
decarboxylase; GAD; EC 4.1. 1.15) began in 1951 with the work of Roberts and his …
decarboxylase; GAD; EC 4.1. 1.15) began in 1951 with the work of Roberts and his …
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
DL Kaufman, MG Erlander… - The Journal of …, 1992 - Am Soc Clin Investig
Insulin-dependent diabetes mellitus (IDDM) is thought to result from the autoimmune
destruction of the insulin-producing beta cells of the pancreas. Years before IDDM …
destruction of the insulin-producing beta cells of the pancreas. Years before IDDM …
GABA and pancreatic beta‐cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic‐like microvesicles suggests their role in GABA storage …
GABA, a major inhibitory neurotransmitter of the brain, is also present at high concentration
in pancreatic islets. Current evidence suggests that within islets GABA is secreted from beta …
in pancreatic islets. Current evidence suggests that within islets GABA is secreted from beta …
GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area
PW Kalivas, L Churchill, MA Klitenick - Neuroscience, 1993 - Elsevier
GABAergic and enkephalinergic afferents to the ventral tegmental area were investigated in
the rat using retrograde tracing techniques combined with in situ hybridization. Following …
the rat using retrograde tracing techniques combined with in situ hybridization. Following …