The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in
B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits …

Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway
is associated with carcinogenesis. A number of key cellular processes are governed by the …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Background: The role of epicardial fat (eFat)-derived extracellular vesicles (EVs) in the
pathogenesis of atrial fibrillation (AF) has never been studied. We tested the hypothesis that …

Protein ubiquitination is involved in virtually all cellular processes. Enrichment strategies
employing antibodies targeting ubiquitin-derived diGly remnants combined with mass …

Factors linking inflammation and cancer are of great interest. We now report that the
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B …

Inflammasome activation is exclusively involved in sensing activation of innate immunity and
inflammatory response during viral infection. Accumulating evidence suggests that the …

Purpose MiR-155 is a member of the microRNAs (miRNAs) family and regulates gene
expression post-transcriptionally by binding to the 3'UTR of target mRNA. MiR-155 has a …

Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors
fundamental in the control of the inflammatory response. The transcription of hundreds of …