Over the past decade the number and variety of protein post-translational modifications that
have been detected and characterized in bacteria have rapidly increased. Most post …

ABSTRACT N ε-Lysine acetylation is now recognized as an abundant posttranslational
modification (PTM) that influences many essential biological pathways. Advancements in …

Posttranslational modification of a protein, either alone or in combination with other
modifications, can control properties of that protein, such as enzymatic activity, localization …

The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates
virulence in response to various signals for bacteria within the mammalian host. Here, we …

Protein acetylation is a universal post-translational modification which is found in both
eukaryotes and prokaryotes. This process is achieved enzymatically by the protein …

Acetate is ubiquitously found in natural environments. Its availability in the gut is high as a
result of the fermentation of nutrients, and although it is rapidly absorbed by intestinal …

In eukaryotes, lactate produced during glycolysis is involved in regulating multiple metabolic
processes through lysine lactylation (Kla). To explore the potential link between metabolism …

Protein acetylation is an evolutionarily conserved posttranslational modification. It affects
enzyme activity, metabolic flux distribution, and other critical physiological and biochemical …

Protein acetylation plays important roles in many biological processes. Malate
dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle, has been identified to …

Increasing evidence shows that protein lysine acetylation is involved in almost every aspect
of cellular physiology in bacteria. Yersinia pestis is a flea-borne pathogen responsible for …