Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …

Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic …

Inflammation is a common element in the pathogenesis of most chronic liver diseases that
lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune …

BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) involves the
innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs) …

The discovery of the NLRP 3 (NLR family, pyrin domain containing 3) inflammasome
provided an important molecular mechanism in the induction of the central pro‐inflammatory …

Cell death and inflammation are two central elements in the development of liver fibrosis.
Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and …

The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

Innate immune signaling associated with Toll‐like receptors (TLRs) is a key pathway
involved in the progression of nonalcoholic steatohepatitis (NASH). Here we show that both …

Worldwide obesity rates have reached epidemic proportions and significantly contribute to
the growing prevalence of metabolic diseases. Chronic low-grade inflammation, a hallmark …