In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Currently, nanosystems have been developed and applied as promising vehicles for
different biomedical applications. We have developed three lignin nanoparticles (LNPs) …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

Polymer conjugation is an efficient approach to improve the delivery of drugs and biological
agents, both by protecting the body from the drug (by improving biodistribution and reducing …

The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of
serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that …

Multiple myeloma (MM) is the second most common hematologic malignancy. Despite
recent treatment advances, it remains incurable. Here, we report that Pim2 kinase …

PIM proteins belong to a family of ser/thr kinases composed of 3 members, PIM1, PIM2 and
PIM3, with greatly overlapping functions. PIM kinases are mainly responsible for cell cycle …

Background/Aims: Natural compounds are a promising resource for anti-tumor drugs.
Myricetin, an abundant flavonoid found in the bark and leaves of bayberry, shows multiple …