Insulin receptor isoforms in physiology and disease: an updated view
A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer
A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …
Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for Alzheimer's disease
SM De la Monte - Drugs, 2017 - Springer
Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …
NAFLD and extra-hepatic comorbidities: current evidence on a multi-organ metabolic syndrome
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with …
worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with …
A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.
R Ștefănescu, A Tero-Vescan, A Negroiu, E Aurică… - Biomolecules, 2020 - mdpi.com
The general spread of Tribulus terrestris L.(South Africa, Australia, Europe, and India), the
high content of active ingredients (in particular sterol saponins, as well as flavonoids …
high content of active ingredients (in particular sterol saponins, as well as flavonoids …
Lipodistrophy: a paradigm for understanding the consequences of “overloading” adipose tissue
K Lim, A Haider, C Adams, A Sleigh… - Physiological …, 2021 - journals.physiology.org
Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …
their rarity, tended to attract considerable medical attention because of the severity and …
[HTML][HTML] Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
Objective A decline in mitochondrial function and biogenesis as well as increased reactive
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …
Adipose tissue dysfunction in cancer cachexia
SI Daas, BR Rizeq, GK Nasrallah - Journal of cellular …, 2019 - Wiley Online Library
Cancer cachexia is a complex disorder that is driven by inflammation and metabolic
imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer …
imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer …
Endocrinology of the aging prostate: current concepts
R Cannarella, RA Condorelli, F Barbagallo… - Frontiers in …, 2021 - frontiersin.org
Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …
In vitro and in vivo effects of IGF-1 delivery strategies on tendon healing: a review
I Miescher, J Rieber, M Calcagni… - International Journal of …, 2023 - mdpi.com
Tendon injuries suffer from a slow healing, often ending up in fibrovascular scar formation,
leading to inferior mechanical properties and even re-rupture upon resumption of daily work …
leading to inferior mechanical properties and even re-rupture upon resumption of daily work …