A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics

RNL Lamptey, B Chaulagain, R Trivedi… - International journal of …, 2022 - mdpi.com
Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …

Transcytosis to cross the blood brain barrier, new advancements and challenges

VM Pulgar - Frontiers in neuroscience, 2019 - frontiersin.org
The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020 - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Targeting the transferrin receptor for brain drug delivery

KB Johnsen, A Burkhart, LB Thomsen… - Progress in …, 2019 - Elsevier
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery

H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

[HTML][HTML] A recent review on cancer nanomedicine

PM Giri, A Banerjee, B Layek - Cancers, 2023 - mdpi.com
Simple Summary The advancement of nanotechnology over the last three decades has
given new hope to cancer management. The first FDA-approved nanomedicine (DOXIL) was …

[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning

M Eshraghi, M Ahmadi, S Afshar, S Lorzadeh… - Pharmacology & …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Combination of cell-penetrating peptides with nanoparticles for therapeutic application: a review

S Silva, AJ Almeida, N Vale - Biomolecules, 2019 - mdpi.com
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane
translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid …

[HTML][HTML] Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

KB Johnsen, A Burkhart, F Melander, PJ Kempen… - Scientific reports, 2017 - nature.com
Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which
excludes most molecules from freely diffusing into the brain, and tightly regulates the active …