A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics
Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …
Transcytosis to cross the blood brain barrier, new advancements and challenges
VM Pulgar - Frontiers in neuroscience, 2019 - frontiersin.org
The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …
the brain. Several strategies aim to overcome this obstacle and promote efficient and …
Ligand‐installed nanocarriers toward precision therapy
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …
Targeting the transferrin receptor for brain drug delivery
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …
development of therapeutics to treat diseases of the central nervous system. The main …
[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery
H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …
it is a challenge to treat central nervous system disorders pharmacologically. The …
[HTML][HTML] A recent review on cancer nanomedicine
PM Giri, A Banerjee, B Layek - Cancers, 2023 - mdpi.com
Simple Summary The advancement of nanotechnology over the last three decades has
given new hope to cancer management. The first FDA-approved nanomedicine (DOXIL) was …
given new hope to cancer management. The first FDA-approved nanomedicine (DOXIL) was …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
Combination of cell-penetrating peptides with nanoparticles for therapeutic application: a review
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane
translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid …
translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid …
[HTML][HTML] Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma
Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which
excludes most molecules from freely diffusing into the brain, and tightly regulates the active …
excludes most molecules from freely diffusing into the brain, and tightly regulates the active …