Natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms

J Sharifi-Rad, N Cruz-Martins… - Oxidative Medicine …, 2021 - Wiley Online Library
Coumarins belong to the benzopyrone family commonly found in many medicinal plants.
Natural coumarins demonstrated a wide spectrum of pharmacological activities, including …

An overview of spirooxindole as a promising scaffold for novel drug discovery

LM Zhou, RY Qu, GF Yang - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

An insight into the therapeutic applications of coumarin compounds and their mechanisms of action

SS Garg, J Gupta, S Sharma, D Sahu - European Journal of Pharmaceutical …, 2020 - Elsevier
The coumarins are heterocyclic compounds belonging to the class of benzopyrone enriched
in various plants like tonka beans. Coumarins and their derivatives exert a vast array of …

Current developments of coumarin compounds in medicinal chemistry

XM Peng, G LV Damu, H Zhou - Current pharmaceutical …, 2013 - ingentaconnect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Seven metal-based bi-dentate NO azocoumarine complexes: Synthesis, physicochemical properties, DFT calculations, drug-likeness, in vitro antimicrobial screening …

A Abdou, HM Mostafa, AMM Abdel-Mawgoud - Inorganica Chimica Acta, 2022 - Elsevier
Abstract Herein, new Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) complexes based
on azocoumarin ligand, 2-[(E)-(2-oxo-2H-chromen-6-yl) diazenyl]-1-phenylbutane-1, 3 …

Novel cyclohepta [b] thiophene derivative incorporating pyrimidine, pyridine, and chromene moiety as potential antimicrobial agents targeting DNA gyrase

EA Fayed, M Mohsen, SM Abd El-Gilil… - Journal of Molecular …, 2022 - Elsevier
The emergence of drug-resistant microbes is responsible for high morbidity and mortality
worldwide. In our endeavors to cultivate novel and effectual antimicrobial agents, we present …

Inhibition effects of a synthesized novel 4-aminoantipyrine derivative on the corrosion of mild steel in hydrochloric acid solution together with quantum chemical …

S Junaedi, AA Al-Amiery, A Kadihum… - International journal of …, 2013 - mdpi.com
1, 5-Dimethyl-4-((2-methylbenzylidene) amino)-2-phenyl-1 H-pyrazol-3 (2 H)-one (DMPO)
was synthesized to be evaluated as a corrosion inhibitor. The corrosion inhibitory effects of …

Antioxidant capacity and the correlation with major phenolic compounds, anthocyanin, and tocopherol content in various extracts from the wild edible Boletus edulis …

E Vamanu, S Nita - BioMed research international, 2013 - Wiley Online Library
Boletus edulis is a wild edible mushroom habitually consumed by rural populations.
Ethanolic and methanolic extracts was obtained in cold and hot water from dried fruit bodies …

Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment

Q Li, Y Yang, Y Li, Y Mi, X Ma, A Jiang, Z Guo - International Journal of …, 2023 - Elsevier
Natural polysaccharides are abundant and renewable resource, but their applications are
hampered by limited biological activity. Chemical modification can overcome these …

Electrochemical and quantum chemical evaluation of new bis (coumarins) derivatives as corrosion inhibitors for carbon steel corrosion in 0.5 M H2SO4

M Abd El-Raouf, EA Khamis, MTH Abou Kana… - Journal of Molecular …, 2018 - Elsevier
Four new bis (coumarin) compounds were prepared and their structures were confirmed
using elemental analysis FTIR, 1 H NMR and mass spectroscopy. The corrosion inhibition …