New drugs are urgently needed for the treatment of tropical and subtropical parasitic
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …

Sulfur-containing amino acids play indispensable roles in a wide variety of biological
activities including protein synthesis, methylation, and biosynthesis of polyamines and …

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …

Vitamin B6 is an essential cofactor for more than 100 enzymatic reactions. Mammalian cells
are unable to synthesize vitamin B6 de novo, whereas bacteria, plants, fungi, and as shown …

More than 30 years ago the potent ornithine decarboxylase inhibitor difluoromethylornithine
(DFMO) was designed as new anticancer drug. Its efficacy was not as expected since the …

Plasmodium falciparum encodes∼ 5300 proteins of which∼ 35% have repeats of amino
acids, significantly higher than in other fully sequenced eukaryotes. The proportion of …

The human malaria parasite Plasmodium falciparum genome is among the most A+ T rich,
with low complexity regions (LCRs) inserted in coding sequences including those for …

There is an urgent need for the identification and validation of new therapeutic targets in
protozoan parasites because currently available drugs are limited in number and …

The 2.15 Å resolution crystal structure of arginase from Plasmodium falciparum, the parasite
that causes cerebral malaria, is reported in complex with the boronic acid inhibitor 2 (S) …

Prior to infecting erythrocytes and causing malaria symptoms, Plasmodium parasites
undergo an obligatory phase of invasion and extensive replication inside their mammalian …