Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks
(DSBs), it is always followed by the phosphorylation of the histone, H2AX. H2AX is a variant …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant,
H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is …

Context: Medullary thyroid cancer (MTC) is a rare thyroid cancer that can occur sporadically
or as part of a hereditary syndrome. Objective: To explore the genetic origin of MTC, we …

Low doses of radiation may have profound effects on cellular function. Individuals may be
exposed to low doses of radiation either intentionally for medical purposes or accidentally …

Current advances in cancer biology have identified major pathways involved in
tumorigenesis. The association of DNA damage with premalignant stages of tumor …

Abstract Background Neuroendocrine neoplasms (NENs) represent a heterogeneous class
of rare tumors with increasing incidence. They are characterized by the ability to secrete …

The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local
activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has …

Background Cisplatin is a widely used cancer chemotherapeutic drug that causes DNA
crosslinking and stimulates H2AX phosphorylation. Our goal was to assess the potential of …