Marine natural products: A source of novel anticancer drugs

SAM Khalifa, N Elias, MA Farag, L Chen, A Saeed… - Marine drugs, 2019 - mdpi.com
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new
drugs with novel modes of action and thus considerable research has been conducted for …

Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms

S Romano, SA Jackson, S Patry, ADW Dobson - Marine drugs, 2018 - mdpi.com
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …

[HTML][HTML] Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds

F Alsenani, KR Tupally, ET Chua, E Eltanahy… - Saudi Pharmaceutical …, 2020 - Elsevier
In recent decades, marine microorganisms have become known for their ability to produce a
wide variety of secondary bioactive metabolites. Several compounds have been isolated …

Halophiles and their biomolecules: recent advances and future applications in biomedicine

P Corral, MA Amoozegar, A Ventosa - Marine drugs, 2019 - mdpi.com
The organisms thriving under extreme conditions better than any other organism living on
Earth, fascinate by their hostile growing parameters, physiological features, and their …

The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

PR Jensen, BS Moore, W Fenical - Natural product reports, 2015 - pubs.rsc.org
Covering: 2001 to 2014 This review covers the initial discovery of the marine actinomycete
genus Salinispora through its development as a model for natural product research. A focus …

Metabolomics on the study of marine organisms

LM Bayona, NJ de Voogd, YH Choi - Metabolomics, 2022 - Springer
Background Marine ecosystems are hosts to a vast array of organisms, being among the
most richly biodiverse locations on the planet. The study of these ecosystems is very …

Identification of nutritional components in black sesame determined by widely targeted metabolomics and traditional Chinese medicines

D Wang, L Zhang, X Huang, X Wang, R Yang, J Mao… - Molecules, 2018 - mdpi.com
Chemical composition of secondary metabolites is of great importance for quality control of
agricultural products. Black sesame seeds are significantly more expensive than white …

Natural products diversity of marine ascidians (Tunicates; Ascidiacea) and successful drugs in clinical development

SK Palanisamy, NM Rajendran, A Marino - Natural products and …, 2017 - Springer
This present study reviewed the chemical diversity of marine ascidians and their
pharmacological applications, challenges and recent developments in marine drug …

Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds

MMP Tangerina, LC Furtado, VMB Leite… - PLoS …, 2020 - journals.plos.org
Resorting to a One Strain Many Compounds (OSMAC) approach, the marine Streptomyces
sp. BRB081 strain was grown in six different media settings over 1, 2, 3 or 7 days …

Metabolomic tools used in marine natural product drug discovery

KA Stuart, K Welsh, MC Walker… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The marine environment is a very promising resource for natural product
research, with many of these reaching the market as new drugs, especially in the field of …