Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that
currently combines the selectivity of monoclonal antibodies with the potency of a payload …

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new
therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core …

Cancer cells are dependent upon an abundance of ribosomes to maintain rapid cell growth
and proliferation. The rate-limiting step of ribosome biogenesis is ribosomal RNA (rRNA) …

Nonsense mutations–the underlying cause of approximately 11% of all genetic diseases–
prematurely terminate protein synthesis by mutating a sense codon to a premature stop or …

In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …

The current management of breast cancer (BC) lacks specific non‑invasive biomarkers able
to provide an early diagnosis of the disease. Epigenetic‑sensitive signatures are influenced …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …

Human viral oncogenesis is a complex phenomenon and a major contributor to the global
cancer burden. Several recent findings revealed cellular and molecular pathways that …