Innate immunity against HIV-1 infection
M Altfeld, M Gale Jr - Nature immunology, 2015 - nature.com
During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …
Recognition of viruses by cytoplasmic sensors
C Wilkins, M Gale Jr - Current opinion in immunology, 2010 - Elsevier
The immune response to virus infection is initiated when pathogen recognition receptors
(PRRs) of the host cell recognize specific nonself-motifs within viral products (known as a …
(PRRs) of the host cell recognize specific nonself-motifs within viral products (known as a …
IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease
AA Negash, HJ Ramos, N Crochet, DTY Lau… - PLoS …, 2013 - journals.plos.org
Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver
inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the …
inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the …
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
MR Jakobsen, RO Bak, A Andersen… - Proceedings of the …, 2013 - National Acad Sciences
Replication of lentiviruses generates different DNA forms, including RNA: DNA hybrids,
ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and pattern …
ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and pattern …
The IFITM proteins inhibit HIV-1 infection
Type I interferon protects cells from virus infection through the induction of a group of genes
collectively named interferon-stimulated genes (ISGs). In this study, we utilized short hairpin …
collectively named interferon-stimulated genes (ISGs). In this study, we utilized short hairpin …
Viral and host mediators of non-suppressible HIV-1 viremia
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
Early events in sexual transmission of HIV and SIV and opportunities for interventions
AT Haase - Annual review of medicine, 2011 - annualreviews.org
To constrain the growth of the HIV/AIDS pandemic and ultimately end it, effective measures
must be developed to prevent sexual mucosal transmission, the major route by which new …
must be developed to prevent sexual mucosal transmission, the major route by which new …
Human dendritic cell subsets, ontogeny, and impact on HIV infection
JW Rhodes, O Tong, AN Harman… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …
pathogens, representing one of the first responders to infection by mucosal invaders. From …
[HTML][HTML] Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
N Laguette, C Brégnard, P Hue, J Basbous, A Yatim… - Cell, 2014 - cell.com
The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we
show that G2/M arrest results from untimely activation of the structure-specific endonuclease …
show that G2/M arrest results from untimely activation of the structure-specific endonuclease …
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production
N Nasr, S Maddocks, SG Turville… - Blood, The Journal …, 2012 - ashpublications.org
Macrophages are key target cells for HIV-1. HIV-1BaL induced a subset of interferon-
stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in …
stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in …