Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

Background Oxidative stress, defined as an imbalance between pro-oxidants and
neutralizing antioxidants within the body, is a growing public health concern. Oxidative …

Sleep, constituting approximately one‐third of the human lifespan, is a crucial physiological
process essential for physical and mental well‐being. Normal sleep consists of an orderly …

Sleep disorders affect millions of people around the world and have a high comorbidity with
psychiatric disorders. While current hypnotics mostly increase non-rapid eye movement …

The association of chronic pain with depression is becoming increasingly recognized.
Treating both the conditions together is essential for an effective treatment outcome. In this …

Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and
angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor …

The use of exogenous melatonin (exo-MEL) as a sleep-promoting drug has been under
extensive debate due to the lack of consistency of its described effects. In this study, we …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …

Abstract Melatonin (MT; N‑acetyl‑5‑methoxy‑tryptamine), which has multiple effects and
roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to …