Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and
pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic …

Sexual dimorphisms in humans and other species exist in visually evident features such as
body size and less apparent characteristics, including disease prevalence. Current research …

Background Traumatic heterotopic ossification (HO) is a devastating sequela of orthopedic
surgeries and traumatic injuries; however, few studies have explored the effects of the …

Mesenchymal stem/stromal cells (MSCs) are a promising therapeutic tool in cell therapy and
tissue engineering because of their multi-lineage differentiation capacity …

Human adipose-derived mesenchymal stem cells (ASCs) transduced with a lentiviral vector
system to express bone morphogenetic protein 2 (LV-BMP-2) have been shown to reliably …

Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs)
due to their multi‐potent potential and ability to generate a pro‐regenerative secretome …

Background. Fibrin sealant has been used as a scaffold to deliver genetically modified
human muscle-derived stem cells (hMDSCs) for bone regeneration. Alternatively …

Mesenchymal stromal cells (MSCs) have the potential for novel treatments of several
musculoskeletal conditions due to their ability to differentiate into several cell lineages …

Regenerative rehabilitation is a promising field aimed at harnessing the regenerative
potential of stem cell therapeutics to maximize functional recovery. Here, we outline recent …

ABSTRACT Background Checkpoint kinase 2 (CHEK2) and its regulated tumor protein p53
(TP53) have been correlated with osteogenic differentiation of osteoblast-like cells. Based …