Periodontitis is a chronic inflammatory disease, initiated by the presence of a bacterial
biofilm, called dental plaque, which affects both the periodontal ligaments and bone …

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary
arteries associated with atheroma formation, which can cause disability and often death …

Toll-like receptors play a critical role in innate immunity by detecting invading pathogens.
The ability of TLRs to engage different intracellular signaling molecules and cross-talk with …

Most commensal and pathogenic bacteria interacting with eukaryotic hosts express
adhesive molecules on their surfaces that promote interaction with host cell receptors or with …

Objective The objective of this review was to perform a systematic evaluation of the literature
reporting current scientific evidence for periodontal bacteria as contributors to …

Even though animal models have limitations, they are often superior to in vitro or clinical
studies in addressing mechanistic questions and serve as an essential link between …

In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …

The Toll-like receptors (TLRs) and complement are key innate defense systems that are
triggered rapidly upon infection. Although both systems have been investigated primarily as …

Outer membrane vesicles (OMVs) are proteoliposomes blebbed from the surface of Gram-
negative bacteria. Chronic periodontitis is associated with an increase in subgingival plaque …

Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the
modern community. Both pathologies are chronic inflammatory disorders, which are …