Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
Stepping forward in antibody-drug conjugate development
Y Jin, MA Schladetsch, X Huang, MJ Balunas… - Pharmacology & …, 2022 - Elsevier
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …
Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
L Liu - Protein & cell, 2018 - academic.oup.com
There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion
molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc …
molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc …
Non-specificity as the sticky problem in therapeutic antibody development
Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …
products approved on the market. Successful development of antibody-based drugs …
FGFR a promising druggable target in cancer: Molecular biology and new drugs
Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …
[HTML][HTML] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors
The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …
an important role in normal organ, vascular, and skeletal development. Deregulation of …
[HTML][HTML] Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies
AV Kamath - Drug Discovery Today: Technologies, 2016 - Elsevier
Monoclonal antibodies (mAbs) are an important therapeutic class with complex
pharmacology and interdependent pharmacokinetic (PK) and pharmacodynamics (PD) …
pharmacology and interdependent pharmacokinetic (PK) and pharmacodynamics (PD) …
A strategy for risk mitigation of antibodies with fast clearance
I Hötzel, FP Theil, LJ Bernstein, S Prabhu, R Deng… - MAbs, 2012 - Taylor & Francis
A majority of human therapeutic antibody candidates show pharmacokinetic properties
suitable for clinical use, but an unexpectedly fast antibody clearance is sometimes observed …
suitable for clinical use, but an unexpectedly fast antibody clearance is sometimes observed …
[HTML][HTML] Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges
Significant progress has been made in understanding pharmacokinetics (PK),
pharmacodynamics (PD), as well as toxicity profiles of therapeutic proteins in animals and …
pharmacodynamics (PD), as well as toxicity profiles of therapeutic proteins in animals and …