Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Telomere biology was first studied in maize, ciliates, yeast, and mice, and in recent decades,
it has informed understanding of common disease mechanisms with broad implications for …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Telomere length in humans is associated with lifespan and severe diseases, yet the genetic
determinants of telomere length remain incompletely defined. Here we performed genome …

Understanding why we age is a long-standing question, and many mechanistic theories of
aging have been proposed. Owing to limitations in studying the aging process, including a …

Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

Population-based prospective studies, such as UK Biobank, are valuable for generating and
testing hypotheses about the potential causes of human disease. We describe how UK …

Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …