Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Aging is a degenerative process associated with cumulative damage, which leads to cellular
dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and
mitochondrial genomes have had to closely coordinate their activities, as each encode …

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the
Western world and a major health problem, owing to its close association with obesity …

The liver is a major organ that coordinates the metabolic flexibility of the whole body, which
is characterized by the ability to adapt dynamically in response to fluctuations in energy …

Objective & design Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that refers
to progressive histological changes ranging from simple steatosis (SS) to nonalcoholic …

Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver dysfunctions
and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma …

Background & Aims Severe malnutrition in young children is associated with signs of hepatic
dysfunction such as steatosis and hypoalbuminemia, but its etiology is unknown …

Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …

Insulin resistance (IR) and mitochondrial dysfunction play a central role in the
pathophysiology of nonalcoholic fatty liver disease (NAFLD). We hypothesized that genetic …