Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …

Chromatin-remodelling complexes of the SWI/SNF family function in the formation of
nucleosome-depleted, transcriptionally active promoter regions (NDRs),. In the yeast …

Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …

A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …

Chromatin remodeling ATP ases and their associated complexes can alter the accessibility
of the genome in the context of chromatin by using energy derived from the hydrolysis of …

Chromatin remodeling motors play essential roles in all DNA-based processes. These
motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin …