Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif
ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

The control of cell migration by chemokines involves interactions with two types of receptors:
seven transmembrane chemokine‐type G protein‐coupled receptors and cell surface or …

Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of
physiological and disease-processes. Variations in HS epimerization and sulfation provide …

Glycosaminoglycans are polysaccharides that occur both at the cell surface and within
extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of …

Chemokines have two types of interactions that function cooperatively to control cell
migration. Chemokine receptors on migrating cells integrate signals initiated upon …

Background Acute respiratory distress syndrome (ARDS) is a life-threatening condition
characterised by pulmonary oedema, respiratory failure and severe inflammation. ARDS is …

TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-
inflammatory stimuli by a wide range of cells, including neutrophils, monocytes, and …

Key events that occur during inflammation include the recruitment, adhesion, and
transmigration of leukocytes from the circulation to the site of inflammation. These events are …