Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

E Schrezenmeier, T Dörner - Nature Reviews Rheumatology, 2020 - nature.com
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Novel paradigms in systemic lupus erythematosus

T Dörner, R Furie - The Lancet, 2019 - thelancet.com
The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is
now challenging the entire lupus community, from geneticists to clinical investigators …

Treating systemic lupus erythematosus in the 21st century: new drugs and new perspectives on old drugs

G Ruiz-Irastorza, G Bertsias - Rheumatology, 2020 - academic.oup.com
Besides treating acute flares, the management of SLE should aim at preventing organ
damage accrual and drug-associated harms, improving health-related quality of life and …

New therapeutic strategies in systemic lupus erythematosus management

M Gatto, M Zen, L Iaccarino, A Doria - Nature Reviews Rheumatology, 2019 - nature.com
The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the
recommendations by international medical associations including EULAR and the ACR, is …

Hydroxychloroquine blood levels predict hydroxychloroquine retinopathy

M Petri, M Elkhalifa, J Li, LS Magder… - Arthritis & …, 2020 - Wiley Online Library
Objective In 2016, the American Academy of Ophthalmology (AAO) changed the
recommended daily dose of hydroxychloroquine (HCQ) from 6.5 mg/kg to< 5 mg/kg …

[PDF][PDF] Paediatric rheumatology

RE Petty - Egyptian Pharmaceutical Journal, 2012 - epj.journals.ekb.eg
The last decade has witnessed rapid growth in awareness of the rheumatic diseases of
childhood, an enhanced understanding of many of the unique aspects of their presentation …

Association between severe non‐adherence to hydroxychloroquine and SLE flares, damage, and mortality in 660 patients from the SLICC Inception Cohort

Y Nguyen, B Blanchet, MB Urowitz… - Arthritis & …, 2023 - Wiley Online Library
Objectives To assess the associations of severe non‐adherence to HCQ, objectively
assessed by HCQ serum levels, and risks of SLE flares, damage, and mortality over 5 years …

The main challenges in systemic lupus erythematosus: where do we stand?

M Piga, L Arnaud - Journal of clinical medicine, 2021 - mdpi.com
Systemic lupus erythematosus (SLE) is an immune-mediated multi-systemic disease
characterized by a wide variability of clinical manifestations and a course frequently subject …

Reference range of hydroxychloroquine blood levels that can reduce odds of active lupus and prevent flares

S Garg, B Chewning, P Hutson, BC Astor… - Arthritis Care & …, 2024 - Wiley Online Library
Objective Recent data show that lower hydroxychloroquine (HCQ) doses are associated
with a two‐to six‐fold higher risk of lupus flares. Thus, establishing an effective reference …

Association between severe nonadherence to hydroxychloroquine and systemic lupus erythematosus flares, damage, and mortality in 660 patients from the SLICC …

Y Nguyen, B Blanchet, MB Urowitz… - Arthritis & …, 2023 - Wiley Online Library
Objective The goals of this study were to assess the associations of severe nonadherence to
hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of …