Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

The field of cancer immunotherapy has been re-energized by the application of chimeric
antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are engineered to …

Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma,
the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has …

Tumor-driven immune suppression is a major barrier to successful immunotherapy in
ovarian carcinomas (OvCa). Among various mechanisms responsible for immune …

While the adoption of multimodal therapy including surgery, radiation, and aggressive
combination chemotherapy has improved outcomes for many children with high-risk …

Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen
receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic …

Chimeric antigen receptor (CAR) T cells are engineered constructs composed of synthetic
receptors that direct T cells to surface antigens for subsequent elimination. Many CAR …

Abstract Background Targeting of MDSCs is a major clinical challenge in the era of
immunotherapy. Antibodies which deplete MDSCs in murine models can reactivate T cell …

Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive
tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor …

Polyamines are aliphatic compounds with more than two amino groups that play various
important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs …