The microbiome in autoimmune diseases

F De Luca, Y Shoenfeld - Clinical & Experimental Immunology, 2019 - academic.oup.com
The microbiome is represented by microorganisms which live in a symbiotic way with the
mammalian. Microorganisms have the ability to influence different physiological aspects …

[HTML][HTML] The role of viral infections in the onset of autoimmune diseases

B Sundaresan, F Shirafkan, K Ripperger, K Rattay - Viruses, 2023 - mdpi.com
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

[HTML][HTML] Current clinical trials testing the combination of immunotherapy with radiotherapy

J Kang, S Demaria, S Formenti - Journal for immunotherapy of cancer, 2016 - Springer
Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting
immune mediators that enable anti-tumor responses within and outside the radiation field …

[HTML][HTML] Bullous pemphigoid

D Miyamoto, CG Santi, V Aoki… - Anais brasileiros de …, 2019 - SciELO Brasil
Bullous pemphigoid is the most frequent autoimmune bullous disease and mainly affects
elderly individuals. Increase in incidence rates in the past decades has been attributed to …

[HTML][HTML] Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

M Efremova, D Rieder, V Klepsch… - Nature …, 2018 - nature.com
The cancer immunoediting hypothesis postulates a dual role of the immune system:
protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome …

[HTML][HTML] Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …

An overview of the immune mechanisms of viral myocarditis

N Lasrado, J Reddy - Reviews in medical virology, 2020 - Wiley Online Library
Viral myocarditis has been identified as a major cause of dilated cardiomyopathy (DCM) that
can lead to heart failure. Historically, Coxsackieviruses and adenoviruses have been …

[HTML][HTML] The role of gut microbiota and environmental factors in type 1 diabetes pathogenesis

S Dedrick, B Sundaresh, Q Huang, C Brady… - Frontiers in …, 2020 - frontiersin.org
Type 1 Diabetes (T1D) is regarded as an autoimmune disease characterized by insulin
deficiency resulting from destruction of pancreatic β-cells. The incidence rates of T1D have …

The immune system

PJ Delves, IM Roitt - New England journal of medicine, 2000 - Mass Medical Soc
The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

MJ McGeachy, KS Bak-Jensen, YI Chen, CM Tato… - Nature …, 2007 - nature.com
Studies have shown that transforming growth factor-β (TGF-β) and interleukin 6 (IL-6) are
required for the lineage commitment of pathogenic IL-17-producing T helper cells (TH-17 …