Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Transplantation is an effective approach for treating end-stage organ failure. There has been
a long-standing interest in xenotransplantation as a means of increasing the number of …

Methods for suppressing the host immune system over the long term and improving
transplantation tolerance remain a primary issue in organ transplantation. Cell therapy is an …

This review will detail the current status of islet xenotransplantation as a potential treatment
for type I diabetes mellitus, focusing on recent advances in porcine xenogeneic islet …

Clinical islet transplantation has the potential to cure type 1 diabetes. Despite recent
therapeutic success, it is still uncommon because transplanted islets are damaged by …

The major limitation of organ transplantation is the shortage of available organs from
deceased human donors which leads to the deaths of thousands of patients each year …

Antibody‐mediated rejection (AMR) is the commonest cause of failure of a pig graft after
transplantation into an immunosuppressed nonhuman primate (NHP). The incidence of …

The interleukin (IL)-6/IL-6 receptor-α (IL-6Rα)/signal transduction and activation of the
transcription 3 (STAT3) pathway plays an important role in inflammation. Anti-human IL-6Rα …

Background In pig-to-baboon transplantation models, there is increasing evidence of
systemic inflammation in xenograft recipients (SIXR) associated with pig xenograft failure …

Islet transplantation is a promising treatment for selected patients with type 1 diabetes
mellitus (T1DM). Hypoxia and oxidative stress are major causes of damage to transplanted …