[HTML][HTML] Therapeutic options for management of endometrial hyperplasia

V Chandra, JJ Kim, DM Benbrook… - Journal of …, 2016 - synapse.koreamed.org
Endometrial hyperplasia (EH) comprises a spectrum of changes in the endometrium ranging
from a slightly disordered pattern that exaggerates the alterations seen in the late …

Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization

BS Kumar, A Kumar, J Singh, M Hasanain… - European Journal of …, 2014 - Elsevier
Methoxyestradiol (2ME2) is an investigational anticancer drug. In the present study, 2-
alkoxyesters/acid and 2-benzyloxy analogues of estradiol have been synthesized as …

Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined …

V Chandra, I Fatima, M Manohar, P Popli… - Cell death & …, 2014 - nature.com
Endometrial hyperplasia is a precursor to the most common gynecologic cancer diagnosed
in women. Apart from estrogenic induction, aberrant activation of the Wnt/β-catenin signal is …

Synthesis of combretastatin A4 analogues on steroidal framework and their anti-breast cancer activity

S Parihar, A Kumar, AK Chaturvedi, NK Sachan… - The Journal of steroid …, 2013 - Elsevier
Combretastatin A4 analogues were synthesized on steroidal framework from gallic acid with
a possibility of anti-breast cancer agents. Twenty two analogues were synthesized and …

The regulation of Hh/Gli1 signaling cascade involves Gsk3β-mediated mechanism in estrogen-derived endometrial hyperplasia

JB Kaushal, P Sankhwar, S Kumari, P Popli, V Shukla… - Scientific reports, 2017 - nature.com
The present study was undertaken to explore the functional involvement of Hh signaling and
its regulatory mechanism in endometrial hyperplasia. Differential expression of Hh signaling …

The anti-proliferative effect of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo (b) pyran is potentiated via induction of estrogen receptor beta and p21 in …

I Fatima, R Saxena, G Kharkwal, MK Hussain… - The Journal of Steroid …, 2013 - Elsevier
In an effort to develop novel therapeutic agents for endometrial cancer, benzopyran
derivatives synthesized at our institute display significant inhibitory activity on cellular growth …

2, 3-Diaryl-2H-1-benzopyran derivatives interfere with classical and non-classical estrogen receptor signaling pathways, inhibit Akt activation and induce apoptosis in …

I Fatima, V Chandra, R Saxena, M Manohar… - Molecular and cellular …, 2012 - Elsevier
OBJECTIVES: The present study was undertaken to explore the mechanism of anti-
proliferative action of benzopyran compound D1 (2-[piperidinoethoxyphenyl]-3-phenyl-2H …

Apoptosis induction and inhibition of hyperplasia formation by 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo (b) pyran in rat uterus

V Chandra, I Fatima, R Saxena, S Kitchlu… - American Journal of …, 2011 - Elsevier
OBJECTIVE: The study was undertaken to explore the antiproliferative mechanism of action
of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo (b) pyran (K-1) in estradiol …

Synthesis of CdS nanoparticle and reveal its effect on reproductive system of male albino rats

V Kumar Bajaj, A Goyal, G Sharma, K Bala Sharma… - BioNanoScience, 2013 - Springer
This is a controlled research laboratory study (conducted in the research laboratory of the
University of Rajasthan) which shows synthesis of CdS nanoparticle (NPs) and its effects on …

Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo (b) pyran: Evidence for involvement of GPR30/EGFR signaling pathway

V Chandra, I Fatima, R Saxena, MK Hussain… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: The aim of the present study was to investigate the effect of non-steroidal, pure
antiestrogenic benzopyran derivative ie, 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H …