Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead
S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …
formulate poor water soluble compounds for bioavailability enhancement. However, certain …
Novel Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Oral Delivery of Cinnarizine: Design, Optimization, and In-Vitro Assessment
Due to its extreme lipophilicity, the oral delivery of cinnarizine (CN) encounters several
problems such as poor aqueous solubility and pH-dependent dissolution, which result in low …
problems such as poor aqueous solubility and pH-dependent dissolution, which result in low …
[HTML][HTML] Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and
thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid …
thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid …
Self-emulsifying phospholipid pre-concentrates (SEPPs) for improved oral delivery of the anti-cancer genistein: Development, appraisal and ex-vivo intestinal …
Genistein (GEN), a potent anticancer agent, suffers from scanty oral bioavailability due to
poor solubility and extensive metabolism. This work endeavored to enhance GEN solubility …
poor solubility and extensive metabolism. This work endeavored to enhance GEN solubility …
In vitro methods for in vitro-in vivo correlation (IVIVC) for poorly water soluble drugs: lipid based formulation perspective
A great number of new drug candidates identified from the discovery pipeline are poorly
water soluble, which is a drawback to bring such candidates into the pharmaceutical market …
water soluble, which is a drawback to bring such candidates into the pharmaceutical market …
[HTML][HTML] Adsorbent precoating by lyophilization: A novel green solvent technique to enhance cinnarizine release from solid self-nanoemulsifying drug delivery systems …
Background: Solidification by high surface area adsorbents has been associated with major
obstacles in drug release. Accordingly, new approaches are highly demanded to solve …
obstacles in drug release. Accordingly, new approaches are highly demanded to solve …
[HTML][HTML] Oral bioactive self-nanoemulsifying drug delivery systems of remdesivir and baricitinib: a paradigmatic case of drug repositioning for cancer management
Oral anticancer therapy mostly faces the challenges of low aqueous solubility, poor and
irregular absorption from the gastrointestinal tract, food-influenced absorption, high first-pass …
irregular absorption from the gastrointestinal tract, food-influenced absorption, high first-pass …
Self-emulsifying Preconcentrates of daidzein–phospholipid Complex: design, In Vitro and In Vivo Appraisal
Aim: Self-emulsifying phospholipid-complex preconcentrates (SEPPs) were fabricated to
improve oral bioavailability of daidzein (DAI), an anticancer drug with challenging …
improve oral bioavailability of daidzein (DAI), an anticancer drug with challenging …
[HTML][HTML] Optimization of self-nanoemulsifying formulations for weakly basic lipophilic drugs: role of acidification and experimental design
Formulators face great challenges in adopting systematic approaches for designing self-
nanoemulsifying formulations (SNEFs) for different drug categories. In this study, we aimed …
nanoemulsifying formulations (SNEFs) for different drug categories. In this study, we aimed …
[HTML][HTML] Brain Targeting by Intranasal Drug Delivery: Effect of Different Formulations of the Biflavone “Cupressuflavone” from Juniperus sabina L. on the Motor Activity …
The polar fractions of the Juniperus species are rich in bioflavonoid contents. Phytochemical
study of the polar fraction of Juniperus sabina aerial parts resulted in the isolation of …
study of the polar fraction of Juniperus sabina aerial parts resulted in the isolation of …