The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

Construction of multifunctional nanoplatforms to elevate chemotherapeutic efficacy and
induce long‐term antitumor immunity still remains to be an extreme challenge. Herein, the …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …

The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is
triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells …

Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with the
dysregulation of lipid metabolism and hepatic inflammation, though the underlying …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

Amplification of endoplasmic reticulum stress (ERS) to realize enhanced cancer therapy has
been considered to be unique in current cancer nanomedicine design. Herein, the design of …

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …