Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

The global infertility rate has been declining from year to year. PCOS is one of the treatable
accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of …

Purpose To evaluate the relationship between apoptosis of granulosa cells in women with
normal ovarian reserve versus diminished ovarian reserve, and relate that to follicular fluid …

The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa
cells are essential in normal follicular maturation process since they produce steroidal …

Purpose: The aim was to establish the impact of human granulosa cell apoptosis and
reactive oxygen species (ROS) production on fertilization competence of the oocyte, embryo …

The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …

Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential
pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood …

OBJECTIVE: To test if a high degree of apoptosis in cumulus cells could indicate diminished
oocyte quality and developmental competence. DESIGN: Prospective analysis. SETTING …

Purpose To determine the level of apoptosis, and alteration of FoxO3 (forkhead box O3
transcription factor) expression and phosphorylation in human granulosa cells amongst …

It has been suggested recently that, in some quarters, IVF be offered as first-line therapy to
all infertile couples, regardless of the type of infertility. Hence, the time was thought right to …