Clonal expansion of B cells and the production of oligoclonal IgG in the brain and
cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) have long been interpreted …

Multiple sclerosis (MS) is an autoimmune disorder of the brain and spinal cord that
predominantly affects white matter. MS has a variable clinical presentation and has no …

Multiple sclerosis is a debilitating disease of the central nervous system that has been
characteristically classified as an immune‐mediated destruction of myelin, the protective …

Growing evidence suggests that axonal degeneration rather than demyelination is the
pathological substrate underlying chronic, irreversible disability in multiple sclerosis …

We describe here the paradoxical development of spontaneous experimental autoimmune
encephalomyelitis (EAE) in transgenic mice expressing a myelin oligodendrocyte …

Maintaining the appropriate complement and content of lipids in cellular membranes is
critical for normal neural function. Accumulating evidence suggests that even subtle …

Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in
COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity …

The immune system is inextricably linked with many neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor …

Drainage of central nervous system (CNS) antigens to the brain-draining cervical lymph
nodes (CLN) is likely crucial in the initiation and control of autoimmune responses during …

Multiple sclerosis (MS) is an autoimmune disease of unknown cause, in which chronic
inflammation drives multifocal demyelination of axons in both white and gray matter in the …