Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Klebsiella variicola: an emerging pathogen in humans

N Rodríguez-Medina, H Barrios-Camacho… - Emerging microbes & …, 2019 - Taylor & Francis
The Klebsiella pneumoniae complex comprises seven K. pneumoniae-related species,
including K. variicola. K. variicola is a versatile bacterium capable of colonizing different …

[HTML][HTML] A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

MMC Lam, RR Wick, SC Watts, LT Cerdeira… - Nature …, 2021 - nature.com
Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-
associated infections, neonatal sepsis and community-acquired liver abscess, and is …

[HTML][HTML] Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A Eskenazi, C Lood, J Wubbolts, M Hites… - Nature …, 2022 - nature.com
A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella
pneumoniae infection after long-term (> 700 days) antibiotic therapy is treated with a pre …

Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a …

M Wang, M Earley, L Chen, BM Hanson… - The Lancet Infectious …, 2022 - thelancet.com
Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

[HTML][HTML] Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low-and middle-income countries

K Sands, MJ Carvalho, E Portal, K Thomson… - Nature …, 2021 - nature.com
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of resistance that often
spread between species via mobile genetic elements, ultimately limiting treatments in low …

Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella pneumoniae species complex

MMC Lam, RR Wick, LM Judd, KE Holt… - Microbial …, 2022 - microbiologyresearch.org
The outer polysaccharide capsule and lipopolysaccharide (LPS) antigens are key targets for
novel control strategies targeting Klebsiella pneumoniae and related taxa from the K …

[HTML][HTML] Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

KL Wyres, RR Wick, LM Judd, R Froumine… - PLoS …, 2019 - journals.plos.org
Klebsiella pneumoniae has emerged as an important cause of two distinct public health
threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible …

[HTML][HTML] Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

AC Dowell, MS Butler, E Jinks, G Tut, T Lancaster… - Nature …, 2022 - nature.com
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for
this outcome is unclear. Here we compare antibody and cellular immunity in children (aged …

Identification of Acinetobacter baumannii loci for capsular polysaccharide (KL) and lipooligosaccharide outer core (OCL) synthesis in genome assemblies using curated …

KL Wyres, SM Cahill, KE Holt, RM Hall… - Microbial …, 2019 - microbiologyresearch.org
Multiply antibiotic-resistant Acinetobacter baumannii infections are a global public health
concern and accurate tracking of the spread of specific lineages is needed. Variation in the …