Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

[HTML][HTML] Endothelial dysfunction in diabetes: the role of reparatory mechanisms

A Avogaro, M Albiero, L Menegazzo… - Diabetes …, 2011 - ncbi.nlm.nih.gov
Type 2 diabetes is characterized by a two-to fourfold increased risk of cardiovascular
disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative …

Human endothelial progenitor cells

MC Yoder - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells
that express a variety of cell surface markers similar to those expressed by vascular …

Autologous stem cell therapy for peripheral arterial disease: meta-analysis and systematic review of the literature

GP Fadini, C Agostini, A Avogaro - Atherosclerosis, 2010 - Elsevier
BACKGROUND: Peripheral arterial disease (PAD) is a common cause of disability and
mortality. Up to one third of patients are not susceptible to traditional revascularization and …

Diabetes impairs stem cell and proangiogenic cell mobilization in humans

GP Fadini, M Albiero, S Vigili de Kreutzenberg… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Diabetes mellitus (DM) increases cardiovascular risk, at least in part, through
shortage of vascular regenerative cells derived from the bone marrow (BM). In experimental …

Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau

GP Fadini, I Baesso, M Albiero, S Sartore, C Agostini… - Atherosclerosis, 2008 - Elsevier
In the last 10 years an increasing interest has been devoted to the study of endothelial
progenitor cells (EPCs), a subtype of immature cells involved in endothelial repair and …

Circulating stem cells and cardiovascular outcomes: from basic science to the clinic

GP Fadini, A Mehta, DS Dhindsa… - European heart …, 2020 - academic.oup.com
The cardiovascular and haematopoietic systems have fundamental inter-relationships
during development, as well as in health and disease of the adult organism. Although …

Endothelial activation and circulating markers of endothelial activation in kidney disease

TJ Rabelink, HC De Boer… - Nature Reviews …, 2010 - nature.com
The recognition of a central role for the endothelium in the development of kidney disease or
the development of vascular lesions in patients with established renal dysfunction has led to …

Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes

GP Fadini, E Boscaro, S De Kreutzenberg… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE Reduction of bone marrow–derived circulating progenitor cells has been
proposed as a novel mechanism of cardiovascular disease in type 2 diabetes. The present …

Endothelial progenitor cells in the natural history of atherosclerosis

GP Fadini, C Agostini, S Sartore, A Avogaro - Atherosclerosis, 2007 - Elsevier
Atherosclerotic diseases are responsible for a significant part of morbidity and mortality in
western countries. According to the classical views, atherosclerotic lesions develop as the …