[HTML][HTML] Faces of cellular senescence in skin aging
CY Ho, O Dreesen - Mechanisms of Ageing and Development, 2021 - Elsevier
The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …
Gadd45 in stress signaling, cell cycle control, and apoptosis
The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is
often induced by DNA damage and other stress signals associated with growth arrest and …
often induced by DNA damage and other stress signals associated with growth arrest and …
[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
The molecular biology of cancer
JS Bertram - Molecular aspects of medicine, 2000 - Elsevier
The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …
known to require the sequential acquisition of mutations which arise as a consequence of …
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway
Y Ziv, D Bielopolski, Y Galanty, C Lukas, Y Taya… - Nature cell …, 2006 - nature.com
The cellular DNA-damage response is a signaling network that is vigorously activated by
cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is …
cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is …
GADD45 proteins: central players in tumorigenesis
RE Tamura, JF de Vasconcellos… - Current molecular …, 2012 - ingentaconnect.com
The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
G Barreto, A Schäfer, J Marhold, D Stach… - nature, 2007 - nature.com
DNA methylation is an epigenetic modification that is essential for gene silencing and
genome stability in many organisms. Although methyltransferases that promote DNA …
genome stability in many organisms. Although methyltransferases that promote DNA …
Mechanistic insights into the pharmacological significance of silymarin
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA
MS Kim, M Blake, JH Baek, G Kohlhagen, Y Pommier… - Cancer research, 2003 - AACR
Several anticancer drugs target DNA or enzymes acting on the DNA. Because chromatin
DNA is tightly compacted, accessibility to the drug target may reduce the efficiency of these …
DNA is tightly compacted, accessibility to the drug target may reduce the efficiency of these …
An informatics approach identifying markers of chemosensitivity in human cancer cell lines
SA Amundson, TG Myers, D Scudiero, S Kitada… - Cancer research, 2000 - AACR
We have used a sensitive and reproducible method of measuring mRNA expression to
compare basal levels of 10 transcripts in the 60 cell lines of the National Cancer Institute's in …
compare basal levels of 10 transcripts in the 60 cell lines of the National Cancer Institute's in …